Aktivace polyolové metabolické dráhy
...neboli sorbitolové cesty.
Při diabetické hyperglykemii vstupuje Glc do buněk inzulin-non-dependentních (pericyty kapilár a neurony). Aldosareduktasa katalyzuje dehydrogenaci Glc a tvoří se D-glucitol.Reakce spotřebovává NADPH, který je potřebný pro udržování hladiny nitrobuněčného glutathionu,důležitého antioxidantu. Stav zvýšeného poměru NADP+/NADPH se také nazývá diabetická pseudohypoxie.
Působením polyoldehydrogenasy (iditoldehydrogenasy) dochází k přeměně D-glucitolu na fruktozu.Polyoldehydrogenasa vykazuje vysokou aktivitu v hepatocytech, spermiích (Fru je hlavním zdrojem energie) a ovariálních buňkách.Naopak malá je její aktivita v retině, lens crystallina, ledvinných tubulech a periferních nervech, tj.tkáních, které jsou na inzulin necitlivé.
Glucitol nedifunduje snadno buněčnými membránami, a proto se hromadí a vyvolává zvýšení osmotického tlaku a tím ICT, čímž dochází k destrukci buněčných struktur.Krystaliny v takto vysoce osmotickém prostředí denaturují a vytvářejí ložiska silně rozptylující světlo.Tak vzniká diabetická katarakta, retinopatie a neuropatie.
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Fani filmów czekają dziś na premiery nie kinowe, ale – online. Zalety serwisów z wideo na żądanie to ciągły dostęp do nowości, możliwość oglądania świetnych produkcji, kiedy mamy ochotę, na różnych urządzeniach: komputerze, telewizorze czy smartfonie. Mamy nieograniczony dostęp do pełnej biblioteki i w ramach subskrypcji możemy oglądać tyle tytułów, ile chcemy. Można przesyłać treści z urządzenia mobilnego na Chromecast i oglądać filmy na ekranie telewizora, nawet jeśli nie jest to Smart TV.
Wśród tegorocznych propozycji znajdują się zarówno filmy fabularne jak i dokumentalne. W tym roku mamy ewidentną przewagę tych pierwszych. Myślę, że te propozycje zainteresują naszych widzów, którzy czekają na dostęp do filmów. Można będzie zobaczyć m.in. "Nocą" lub "Ostatni świadkowie". Z propozycji dokumentalnych chciałabym polecić "Wewnętrzne wojny". To produkcja włosko-ukraińska z ubiegłego roku. Przedstawia historię setek kobie, które postanowiły wstąpić do wojska w 2014 roku. By śledzić ich codzienne życie, reżyserka zrealizowała go w strefie wojennej. To pięknie zrealizowany film, bardzo poruszający, który z pewnością warto zobaczyć – zachęcała w rozmowie.
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(Robertomibe, 16. 5. 2024 21:14)
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5 najlepszych serwisów streamingowych z filmami i serialami
(EddieClano, 18. 5. 2024 11:02)